A20 EARLY-LIFE FUNGAL COLONIZATION MEDIATES HOST METABOLISM AND WHITE ADIPOSE TISSUE INFLAMMATION IN MICE
نویسندگان
چکیده
Abstract Background The gut microbiome has been linked to metabolic diseases including obesity, however the role of fungi (mycobiome) remains understudied. Recently, fungal taxa have correlated with obesity in humans, though their causal contribution development, especially context early life, is unknown. Obesity associated inflammation, alterations white adipose tissue (WAT) immune landscape, which shown be influenced by microbiome. Given potent modulation host immunity mycobiome, it plausible that also influences WAT inflammation. Purpose This research aimed explore early-life colonization specific development and Method Gnotobiotic mice were colonized from birth 12 mouse-derived bacteria (Oligo-MM12) alone or combination Candida albicans Rhodotorula mucilaginosa. Mice weaned onto a control high-fat-high-sugar diet (HFHS) evaluated at weeks for inflammatory outcomes. Result(s) C. reduced body weight fed diet, induced resistance adiposity gain HFHS. In contrast, R. mucilaginosa was increased elevated glycemia LDL-cholesterol Fungal had broad impact on cells tissue. inflammation Th1, Th17, ɣδT cells, ILC1, NK cDC1 neutrophils independently diet. Additionally, vascular macrophages (VAM), CX3CR1+ DCs, ILC3 while HFHS displayed Th2, CD8+ T eosinophils. decreased B VAMs when DCs Interestingly, relative expression mPgc1⍺ mice, indicative enhanced mitochondrial biogenesis. Conclusion(s) Elevated suggests dysfunction energy storage may explain diet-induced changes exacerbate development. work revealed two common colonizers distinct striking prompts inclusion studies metabolism. Please acknowledge all funding agencies checking applicable boxes below CIHR, Other indicate your source Cumming School Medicine Disclosure Interest None Declared
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ژورنال
عنوان ژورنال: Journal of the Canadian Association of Gastroenterology
سال: 2023
ISSN: ['2515-2084', '2515-2092']
DOI: https://doi.org/10.1093/jcag/gwac036.020